Exclusive: Charlie Sheen -- The Talk Show?

The actor also dishes on wrapping up his "Torpedo of Truth" tour and "Two and a Half Men" moving on without him. It's nice to have closure when you hear about scripts being written without me, it's like, okay, we're done. I gave them the apology they wanted, I talked about being open to sit in a room and get involved and all that.," he explains.

Dishing on the rumor that fellow Brat Packer Rob Lowe could replace him on "Men," Sheen replied, "I was actually fine with it. But there's no replacement for me, and that's what the people have said as well."

Sheen also comments on the bin Laden take-down and said, "It's not how you start, it's how you finish, and you know, good on our boys for getting him. So I think it's a start I think."

Charlie is turning his media spotlight on something positive -- bringing awareness to The Juvenile Diabetes Research Foundation and teaming up with baseball great, pal Todd Zeile, whose daughter suffers from the disease. Todd tells Adrianna he thinks the world doesn't know how charitable Sheen is, noting, "The cat's out of the bag tonight."

Sheen opens up about his passion for giving back and reveals, "I always lead with my heart. If I've got the focus of the world on me, why not drive it towards areas and places that need focus." The place he is referring to is Tuscaloosa, Alabama, and the people he wants to help are victims of the devastating tornados that ripped through the South, wiping out homes and killing more than 250 people in six states.

For more information on how you can donate to "Torpedos Against Tornados," visit their website.